Table 2.
Adverse events secondary to topotecan, melphalan and CY regimen
| Toxicity grade 1 | Toxicity grade 2 | Toxicity grade 3 | Toxicity grade 4 | |
|---|---|---|---|---|
| Cardiovascular | Edema: 1 | Edema: 3 Venous thrombus: 1 |
Arrhythmia: 1 Mild heart failure: 1 |
Severe heart failure: 1 |
| General | Fever: 1 Lethargy: 6 |
0 | 0 | 0 |
| Gastrointestinal | Diarrhea: 22 Nausea: 25 Vomiting: 11 Mucositis/stomatitis: 8 |
Diarrhea: 3 Nausea: 10 Mucositis/stomatitis: 18 |
GI Hemorrhage: 1 Vomiting: 1 Mucositis/stomatitis: 13 |
|
| Infection | 3 | 3 | 2 | 0 |
| Metabolic | Hypokalemia: 1 | Hypokalemia: 1 | Hypokalemia: 2 Hypomagnesemia: 1 |
0 |
| Hematological | Leukopenia: 60 Thrombocytopenia: 60 |