Table 3.

Multivariate analysis in predicting overall survival by nuclear features

Variables	Hazard ratio	95% CI	P-value
Nuclear atypia
Moderate vs mild	1.30	0.92–1.83	0.138
Severe vs mild	1.89	1.15–3.10	0.012
Chromatin pattern
Fine granular vs homogeneous	1.52	0.82–2.81	0.181
Coarse granular vs homogeneous	1.06	0.74–1.50	0.754
Prominence of nucleoli
Distinct vs indistinct	0.79	0.48–1.31	0.365
Large vs indistinct	0.81	0.55–1.19	0.280
Mitotic count
Intermediate vs low	1.55	1.05–2.28	0.028
High vs low	2.79	1.69–4.59	<0.001
Atypical mitosis
Presence vs absence	1.02	0.60–1.72	0.948

CI, confidence interval.