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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Matrix Biol. 2014 Jan 26;34:46–54. doi: 10.1016/j.matbio.2013.12.011

Fig. 4.

Fig. 4

Decorin suppresses activation of the anti-autophagic Akt/mTOR/p70S6K pathway. [A] Representative immunoblots depicting P-mTOR (Ser2448), mTOR; P-Akt (S476), Akt; and P-p70S6K (Thr389), p70S6K following treatment with decorin (200 nM) at the indicated time points. [B] Corresponding quantification of phosphorylated Akt, mTOR, and p70S6K as reported in [A] following normalization of the phospho-signal to total Akt, mTOR, and p70S6K, respectively. All experiments have been repeated several times (n = 4–5) with similar kinetics concerning phosphorylation of target proteins in HUVEC while under the influence of decorin.