Table 2.

Spearman’s Rank Correlation Coefficient (ρ) between Promoter (or Gene Body) mCG Density and the Evolutionary Rates (d_N, d_S, and d_N/d_S) for Human–Macaque and Human–Mouse Comparisons Before and After Controlling for Gene Body (or Promoter) mCG Density and Ten Other Confounding Factors

	Before Control			After Control
	dN	dS	dN/dS	dN	dS	dN/dS
Human–macaquea
Promoter methylation	0.2052***	0.0798***	0.1928***	0.1434***	0.0009	0.1601***
Gene body methylation	−0.0975***	−0.0872***	−0.0803***	−0.0607***	−0.0121	−0.0718***
Human–mouseb
Promoter methylation	0.268***	0.1453***	0.2304***	0.1907***	0.0329*	0.1827***
Gene body methylation	−0.096***	−0.0768***	−0.0793***	−0.0289*	0.025	−0.0452***

Note.—The ten confounding factors are N_TF, N_miR, protein connectivity, expression level, tissue specificity, UTR length, intron length, intron number, solvent accessibility, and disorder content.

^aThe analysis was based on 5,128 human genes and their macaque orthologs.

^bThe analysis was based on 5,357 human genes and their mouse orthologs.

*P < 0.05 and ***P < 0.001.