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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Chem Rev. 2014 Jan 28;114(7):3963–4038. doi: 10.1021/cr400443z

Figure 2.

Figure 2

The structure of MoaA from S. aureus. Top, the structure of the dimeric enzyme, with the N- and C-terminal domains of the subunit on the left shaded in blue and green, respectively. Bottom left, a close-up of the active site with S-adenosylmethionine bound to the N-terminal [4Fe-4S] cluster and dithiothreitol bound to the C-terminal [4Fe-4S] (PDB 1TV8). Bottom right, a close-up of the active site of GTP bound to the C-terminal cluster, and methionine bound at the N-terminal cluster; 5′deoxyadenosine is also present in the active site (PDB 2FB3).