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. 2014 Jul 3;7:62. doi: 10.3389/fnmol.2014.00062

FIGURE 1.

FIGURE 1

Input-specific NMDAR-dependent LTD at the thalamic and cortical pathways in the lateral amygdala. (A) Schematic illustration of electrode placement for ppLFS and control pathway recording of the thalamic pathway (left) and the cortical pathway (right). (B) Robust, long-lasting LTD was specifically induced at the pathway receiving ppLFS (thalamic, n = 18; cortical, n = 18) but not at the control pathway (thalamic: n = 11; cortical: n = 14). Insets show representative traces of extracellular field potentials averaged across 10 min before ppLFS (black line) and the last 10 min of recording after ppLFS (gray line). (C) D-APV (50 μM) prevents LTD at thalamic afferents (control: n = 6; D-APV: n = 9) and at cortical afferents (control: n = 5; D-APV: n = 9). Insets show I/O curves on top and below representative traces of extracellular field potentials averaged across 10 min before ppLFS (black line) and the last 10 min of recording after ppLFS (gray line). Data represent mean ± SEM. ***p < 0.001.