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. 2014 Jul 3;7:62. doi: 10.3389/fnmol.2014.00062

FIGURE 2.

FIGURE 2

PP2B and PP1 involvement in LTD at the thalamic and cortical pathways in the lateral amygdala. (A) The PP2B antagonist FK-506 (100 μM) blocks LTD induced at thalamic afferents (left panel, control: n = 5; FK-506: n = 5) and at cortical afferents (right panel, control: n = 5; FK-506: n = 5). (B) The PP1 antagonist tautomycetin (4 nM) blocks LTD induced at thalamic afferents (control: n = 5; tautomycetin: n = 10), and at cortical afferents (control: n = 7; tautomycetin: n = 8). Insets show I/O curves on top and below representative traces of extracellular field potentials averaged across 10 mins before ppLFS (black line) and the last 10 min of recording after ppLFS (gray line). Data represent mean ± SEM. ***p < 0.001, **p < 0.001, *p < 0.05.