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. 2014 Jul 3;7:62. doi: 10.3389/fnmol.2014.00062

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Copyright © 2014 Mirante, Brandalise, Bohacek and Mansuy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NMDAR-dependent LTD in single pyramidal cells. (A) On top, response of a LA cell to current injection of -0.10 and +0.15 nA and below, hyperpolarizing voltage steps of 10 mV from a holding potential of -60 mV were used to measure series resistance. (B) D-APV (50 μM) blocks LA–LTD induced at the thalamic pathway (left panel, control: n = 4; D-APV: n = 3), and at the cortical pathway (right panel, control: n = 5; D-APV: n = 3). Insets show the average of 10 sweeps of a single cell recorded 10 min before (black) and 30 min after (gray) ppLFS. Data represent mean ± SEM. ***p < 0.001, **p < 0.01.