Table 1.
Dengue vaccine formulations and placebo
| Dengue vaccine formulations in vitro potency (log10 focus forming units per milliliter) of each DENV strain |
|---|
| Dengue F17 |
| DENV-1: 4.9 log10 FFU/mL |
| DENV-2: 5.3 log10 FFU/mL |
| DENV-3: 4.7 log10 FFU/mL |
| DENV-4: 5.0 log10 FFU/mL |
| Dengue F19 |
| DENV-1: 4.9 log10 FFU/mL |
| DENV-2: 5.2 log10 FFU/mL |
| DENV-3: 4.6 log10 FFU/mL |
| DENV-4: 4.4 log10 FFU/mL |
| Placebo |
| A sterile solution of EMEM with the same virus stabilizer contained in the vaccine (vegetable-derived carbohydrates and amino acids); the placebo was identical in appearance to the dengue vaccine |
| Viral origin and manufacturer |
| DENV-1: 45AZ5, PDK 27 |
| DENV-2: S16803, PDK 50 |
| DENV-3: CH53489, PDK 20 |
| DENV-4: 341750, PDK 6 |
| All vaccine lots and placebo were produced at the US Army WRAIR Pilot Bioproduction Facility in Silver Spring, MD |
FFU = focus forming units.