Table 4.

Fatal cases by serotype and year

DENV-1
Year	Sex, age	Immunity	Clinical presentation	Immediate cause of death	Initial cause of death
2005	M, 63	Secondary	DHF	Fulminating hepatitis	Dengue
2010	M, 66	ND	Acute renal failure, diabetes	MOF	Associated pathology
2010	M, 15*	ND	DHF/DSS	Ventilator associated pneumonia	Associated pathology
2010	F, 6*	Secondary	DHF/DSS, HbSC Acute thoracic syndrome	MOF	Associated pathology
2010	F, 62	Secondary	DHF/DSS, HbSC	MOF	Associated pathology
2010	M, 90	ND	Heart failure	Cardiogenic shock	Associated pathology
2010	F, 42	ND	DHF/DSS, HbSC	Sudden death	Dengue
2010	M, 80	Secondary	Acute renal failure, diabetes	Acute renal failure	Associated pathology
2010	F, 37	Secondary	DHF/DSS	Sudden death	Dengue
DENV-2
2005	F, 62	Secondary	DHF	Head trauma, cerebral hemorrhage	Associated pathology
2005	M, 53	Secondary	DHF	Fulminating hepatitis	Dengue
2007	M, 59	ND	DHF/DSS	Status epilepticus, ventilator associated pneumonia	Associated pathology
2007	M, 65	Primary	DHF/DSS	Encephalitis	Dengue†
2007	F, 41	Secondary	DHF/DSS	Alithiasic gangrenous cholecystitis, septic shock	Dengue
DENV-4
2010	F, 49	Secondary	DHF/DSS	MOF	Dengue
2010	M, 89	ND	Heart failure	Pneumonia, cardiogenic shock	Associated pathology
2010	M, 1*	ND	DHF/DSS	MOF	Dengue
2010	F, 35	Secondary	DHF/DSS	Sudden death, multifocal myocardial infarction and hepatic necrosis	Dengue†
2010	F, 10*	Secondary	DHF/DSS, HbSC	Shock	Dengue†
2010	F, 49	Primary	DSS	Shock	Dengue
2010	F, 43	Secondary	DHF/DSS	Diabetes, lactic acidosis	Associated pathology

DHF/DSS = dengue hemorrhagic fever/dengue shock syndrome according to WHO definition⁶; ND = not determined; MOF = multiple organ failure; HbSC = sickle cell disease (SC type).

^*Not included in the study cohort.

^†Autopsy case.