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. 2014 Jun 20;11:112. doi: 10.1186/1742-2094-11-112

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Copyright © 2014 Kong et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Protective effect of anti-CKLF1 on cerebral infarct volume. Bar graph shows effects of anti-CKLF1 antibody on infarct volume at 24 and 72 hours after reperfusion. Anti-CKLF1 antibody (0.1, 0.5 or 1 μg) was injected into the right cerebral ventricle immediately after reperfusion. The white area represents the area of infarction in the brains of ischemic rats and the non-ischemic area is red. Animals treated with anti-CKLF1 antibody showed less cerebral infarction in a dose-dependent manner compared to vehicle. Normal rabbit IgG had no significant effect. Each data point shows the mean ± SEM for six rats. *P < 0.05, **P < 0.01, ***P < 0.001, compared with vehicle group.