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. 2014 Jun 20;11:112. doi: 10.1186/1742-2094-11-112

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Copyright © 2014 Kong et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of anti-CKLF1 antibody on mitogen-activated protein kinase (MAPK) signal pathways. Anti-CKLF1 antibody (0.1, 0.5 or 1 μg) was injected into the right cerebral ventricle immediately after reperfusion. MAPK signal proteins were measured in ischemic cortex. Treatment with anti-CKLF1 antibody inhibited the phosphorylation level of p38, ERK and JNK in the rat ischemic cortex. Each data point shows the mean ± SEM for five rats. ^##P < 0.01, compared with sham-operated group; *P < 0.05, **P < 0.01, compared with vehicle group.