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. 2014 Jun 19;7:37. doi: 10.1186/1755-8794-7-37

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Copyright © 2014 McErlean et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Influence of disease-status on loci-specific DNA methylation in nasal epithelial cells (NECs). A. Principal component analysis (PCA) of methylation microarray data set (389 probes/sample) revealed a clear separation between Healthy and Asthmatic NECs along PC1. B-C. Cluster analysis of genomic methylation loci revealed patterns characterizing Healthy (B) and Asthma (C) NECs (e.g. Mitotic arrest deficient like-1(yeast)-MAD1L1 for Healthy and Cadherin member 28-CDH28 for Asthma), which were not influenced by virus infection. M-mock, RV- HRV infected.