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. 2014 Jun 19;7:37. doi: 10.1186/1755-8794-7-37

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Copyright © 2014 McErlean et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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DNA methylation status of SNORA12 in Mock or Human Rhinovirus (HRV) infected nasal epithelial cells (NECs). A. Schematic of SNORA12 pyrosequencing assay design. In addition to the CpG targeted by probe cg02440370 (#1), a second CpG (#2) was identified within the coding region. Both CpGs were amplified in bisulphite-specific PCR (Bi-PCR). B. Analysis of SNORA12 methylation in both study populations (see Table 1) revealed a significant increase at CpG#1 within the Healthy NECs during infection. No changes were observed at CpG#2 (data not shown). C. Change in CpG#1 methylation in response to infection for Healthy and Asthmatic NECs. Mean ± SEM ,*p = <0.05. NT – no template control.