Table 2.
Correlation between changes in SNORA12 gene expression and DNA methylation during infection with clinical characteristics of our study populations
| |
Healthy (n = 13) |
Asthma (n = 16) |
Both Groups |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
Expression |
Methylation |
Expression |
Methylation |
Expression |
Methylation |
||||||
| r s | p value | r s | p value | r s | p value | r s | p value | r s | p value | r s | p value | |
| Atopy |
0.16 |
0.59 |
0.12 |
0.69 |
0.20 |
0.47 |
0.17 |
0.53 |
0.26 |
0.18 |
-0.09 |
0.63 |
| FEV1 (% predicted) |
-0.36 |
0.22 |
0.37 |
0.21 |
0.71 |
0.002 |
0.00 |
0.99 |
0.11 |
0.59 |
0.27 |
0.15 |
| FEV1/FVC (L) |
-0.57 |
0.04 |
-0.09 |
0.76 |
0.43 |
0.10 |
0.23 |
0.39 |
-0.12 |
0.55 |
0.29 |
0.13 |
| PEF (L/min) |
-0.08 |
0.80 |
-0.08 |
0.79 |
-0.13 |
0.64 |
-0.04 |
0.88 |
-0.08 |
0.68 |
0.00 |
1.00 |
| Nasal Allergies |
-0.22 |
0.50 |
0.39 |
0.21 |
0.08 |
0.78 |
-0.02 |
0.95 |
0.13 |
0.51 |
-0.17 |
0.39 |
| Chronic Rhinosinusitis |
0.06 |
0.84 |
0.32 |
0.30 |
-0.15 |
0.58 |
-0.06 |
0.84 |
-0.05 |
0.81 |
0.10 |
0.61 |
| Albuterol use | n/a | n/a | n/a | n/a | -0.29 | 0.28 | 0.07 | 0.80 | -0.01 | 0.96 | -0.21 | 0.27 |
FEV1 – forced expiratory volume in one second. FVC – forced vital capacity. PEF – Peak expiratory Flow. rs – spearmans rho.