Table 3a.
Correlation between donor-specific anti-HLA antibodies (DSA) and engraftment in four patients who experienced graft failure after T-cell depleted haploidentical transplantation with FMT conditioning regimen.
Patient no. | HLA AB type a | Initial titer/before first SCT b | Engrafted Y/N c | After first SCT/before second SCT d | Engrafted Y/N e |
---|---|---|---|---|---|
1 | A 3201 | + + + + | N | + + + + | Y |
2 | A 0211 | + + + | N | + + | N |
B391301 | + + + | + + + | |||
Cw70201 | + + + | NT | |||
DRB1 0404 | + | + | |||
3 | DRB1*0701 | + + | N | − | Y |
DRB4*0101 | + + + | − | |||
DQB1 0202 | + + + | − | |||
4 | None | − | N | − | Y |
Abbreviations: −= < 500; + = 500–1 500; + + = 1 500–3 000; + + + = 3 000–7 000; + + + + = >7000 fluorescence intensity; N = no; Y = yes.
HLA alleles mismatched in the donor for which the patient had DSA at the initial work-up.
Intensity of DSA at the initial work-up/before the first transplant.
Engraftment after the first transplant.
Strength of DSA after the first transplant and/or before the second transplant.
Engraftment after the second transplant.