Table 3b.
Characteristics of four patients tested for DSA who experienced graft failure
| Patient nos. | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
| Donor-specific anti-HLA antibodies | Y | Y | Y | N |
| Age | 43 | 37 | 39 | 29 |
| Gender | F | F | F | M |
| Diagnosis | AML | AML | AML | AML |
| % BM blasts at transplant | 0 | 13 | 23 | 2 |
| Donor | Sib | Sib | Son | Parent |
| Sex mismatch (Y/N) | Y | N | Y | N |
| No. of allele mismatched* | 3 | 4 | 5 | 5 |
| Alloreactive KIR-LM in HVG direction | 0 | 0 | 0 | 0 |
| CMV mismatch (R/D) | R+/D− | R+/D+ | R+/D− | R+/D + |
| ABO mismatch | Major | Minor | Minor | Minor |
| Cell type | PB | PB | PB | PB |
| No. of CD34+ cells infused (× 106/kg) | 14.8 | 6.6 | 17.5 | 11.1 |
| No. of pregnancies | 0 | 3 | 2 | NA |
| No. of PRBCs transfused before transplant | 37 | 41 | 65 | 13 |
Abbreviations: ABO = blood group; D = donor; DSA = donor-specific anti-HLA antibodies; F = female; HVG = host-vs-graft; KIR-LM = killer Ig-like receptor-ligand mismatch; M = male; NA = not applicable; PB = peripheral blood; PRBCs = packed RBCs; R = recipient; Sib = sibling. Patients with antibodies were all females, two out of three multiparous, and all heavily transfused before transplant. *Number of allele mismatches were appreciated on the basis of HLA A, B, C, DRB1, DQB1 typing.