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. Author manuscript; available in PMC: 2014 Jul 3.
Published in final edited form as: Nanotoxicology. 2012 Jun 29;7(6):1070–1081. doi: 10.3109/17435390.2012.702230

Figure 2. Inflammation and airway hyper-reactivity in MWCNT-exposed C57Bl/6 mice is IL-33 dependent.

Figure 2

Acute MWCNT exposure increased airway hyper-reactivity (AHR) (A), the total number of lavageable cells (B), and neutrophil and eosinophil recruitment to the airways (C) in a manner similar to the addition of exogenous recombinant murine IL-33. Inhibiting the IL-33-ST2 signaling axis with systemic delivery of a monoclonal anti- ST2 blocking antibody completely ablated the observed increase in AHR, cellularity, and eosinophilia, but not neutrophilia. Representative images of cell differentials reflect the quantitative data and show the presence of free and alveolar macrophage-associated MWCNT, as well as recruitment of neutrophils and eosinophils (D). Magnification 1000×. n = 5–6, values are means ± SEM; *p < 0.05 compared to vehicle.