Table 1.
Residues of E2 involved in binding to CD81.
| Residuea | Epitopeb | Alternative amino acidsc | Reference |
|---|---|---|---|
| Trp420 | I | – | Owsianka et al. (2006) |
| His421 | I | – | Boo et al. (2012) |
| Trp437 | II | Phe | Drummer et al. (2006) |
| Leu438 | II | Ile,Val, Met | Drummer et al. (2006) |
| Leu441 | II | – | Drummer et al. (2006) |
| Phe442 | II | Leu, Met, Ile | Drummer et al. (2006) |
| Tyr527 | III | – | Owsianka et al. (2006) |
| Trp529 | III | Phe | Owsianka et al. (2006) |
| Gly530 | III | – | Owsianka et al. (2006) |
| Asp535 | III | – | Owsianka et al. (2006) |
| Y613RLWHYd | – | Roccasecca et al. (2003) |
aAnalysis was performed on genotype 1a isolates. bLocation of amino acid within an antigenic region. cAlternative amino acids observed in other isolates of HCV. A dash indicates conserved.dData derived by replacing this region with SAASAS.