Table 1.
Patient characteristics
| HS219 n = 35 | Placebo n = 28 | p -value | |
|---|---|---|---|
| Sex |
|
|
|
| Male |
24 (68.6%) |
19 (67.9%) |
1† |
| Female |
11 (31.4%) |
9 (32.1%) |
|
| Age (years) |
57 ± 11. |
56 ± 11 |
0.585‡ |
| (34, 59, 79) |
(30, 57.5, 76 ) |
||
| Weight before HD (kg) |
59.7 ± 11.0 |
62.0 ± 16.4 |
0.861‡ |
| (40.8, 59.7, 86.7) |
(39.3, 58.3, 120.4) |
||
| Primary disease |
|
|
|
| Chronic glomerulonephritis |
20 |
19 |
0.204‡ |
| Diabetic nephropathy |
8 |
6 |
|
| Nephrosclerosis |
2 |
2 |
|
| Polycystic kidney disease |
0 |
1 |
|
| Others |
5 |
0 |
|
| Duration of dialysis (year) |
8.7 ± 6.8 |
8.7 ± 6.1 |
0.706‡ |
| (0.8, 7.3, 32.9) |
(0.5, 8.2, 24.1) |
||
| Hemodialysis time (hr) |
4.2 ± 0.4 |
4.1 ± 0.3 |
0.978‡ |
| (3.5, 4, 5) |
(3, 4, 5) |
||
| Kt/V |
1.43 ± 0.24 |
1.41 ± 0.22 |
0.718‡ |
| (1.09, 1.37, 2.07) |
(1.10, 1.415, 1.87) |
||
| Salivary flow rate (g/2 min) |
3.91 ± 2.24 |
3.76 ± 1.69 |
0.986‡ |
| (1.02, 3.56, 10.3) |
(1.46, 3.4, 7.42) |
||
| Phosphate binder |
|
|
|
| Calcium carbonate |
18 |
11 |
0.447‡ |
| Sevelamer |
17 |
17 |
|
| Daily dose of phosphate binder |
|
|
|
| Calcium carbonate (g/d) |
2.4 ± 1.3 |
2.8 ± 1.5 |
0.548‡ |
| (1, 2, 6) |
(1, 3, 6) |
||
| Sevelamer hydrochloride (g/d) | 2.7 ± 1.4 |
3.0 ± 2.1 |
0.952‡ |
| (0.75, 3, 5.25) | (0.75, 3, 7.5) |
Age, weight before HD, duration of dialysis, hemodialysis time, Kt/V, salivary flow rate, and daily dose of phosphate binder were presented by mean ± SD (min, median, max).
†Fisher’s exact test, ‡U-test.