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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Radiat Res. 2014 Apr 22;181(5):464–470. doi: 10.1667/RR13672.1

FIG. 4.

FIG. 4

A time course of the radioprotective effects of metformin (Met) in mouse embryo fibroblasts (MEF) at a concentration of 5 mM and an exposure time of 1 h administered from 1 h to 48 h after irradiation with 4 Gy. WR1065 (WR) was administered at a concentration of 4 mM either 30 min before irradiation as a positive control for radioprotective comparison or in combination with Met 1 h or 24 h after irradiation. Each experiment was repeated three times and error bars represent the SEM. P values comparing cell survival levels exposed to 4 Gy only with those exposed to Met and WR alone or in combination are presented for comparison.