TABLE 4.

Medications and Cognitive Impairment

Study	Study Design	Population or Exposure	Sample Size	Findings/Comments
Coluccia 200891	Placebo-controlled, crossover	Chronic prednisone vs. controls	24	-Chronic low dose prednisone treatment did not lead to significant memory impairment compared to controls
				-Patients with acute administration of steroid medication did have memory impairment
Brown 200786	Prospective	Chronic prednisone vs. controls	13	- Cognitive impairment occurring after initiation of prednisone did not lead to further decline over 4 years
Wolf 200184	Placebo-controlled, crossover	Young vs. older	20	- Both young and elderly subjects had transient impairments in short term recall with high dose hydrocortisone
Keenan 199685	Cross-sectional (1) and prospective (2)	Chronic predisone vs. controls	50 (1) and 25 (2)	- Patients on chronic prednisone had more impairments in explicit memory and this was even more significant in elderly subjects
				- After 3 months, of acute prednisone therapy months, there were significant changes in short-term memory from baseline
Varney 198487	Case series	Acute prednisone	6	- Patients developed cognitive impairment after treatment with prednisone that persisted three to eleven months after discontinuation