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. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: Cell Rep. 2014 Feb 27;6(5):818–826. doi: 10.1016/j.celrep.2014.01.045

Figure 1. Pten loss initiates hyperkeratosis in the facial epidermis.

Figure 1

(A and B) 4 week old Le-Cre;Ptenflox/flox or PtenCKO mice displayed hyperkeratosis in cheek and eyelid epidermis (arrows). (C and D) Paraffin sections of the skin revealed the expansion of epidermal layers in PtenCKO mice (arrow). (E and F) X-gal staining indicated specific activity of Le-Cre;R26R in the epidermis (arrows). (G-L) PtenCKO mice exhibited a loss of Pten from the epidermis (H, arrow), increased Ki67 staining denoting proliferation of the basal layer (J, arrow) and expansion of the suprabasal layer shown by K10 positive staining (L, arrow).