. 2014 Jul 1;24(7):1096–1106. doi: 10.1089/thy.2013.0620

Table 2.

Final Surgical Outcomes, by Preoperative Calcitonin Levels and Codon in American Thyroid Association Level A and B RET Mutation Carriers Identified Through Family Screening

		Elevated preoperative CTN				Normal preoperative CTN
ATA level	Codon	Total (n)	Had MTC (n)	Positive predictive value (%)^a	p^b	Total (n)	Had MTC (n)	False-negative rate (%)^c	p^d
B	609	19	16	84	0.60	24	8	33	<0.0001
	611	14	12	86		—	—	—
	618	16	15	94		25	14	48
	620	4	4	100		4	1	20
A	533	37	34	92		3	1	3
	791	4	4	100		9	0	0
	804	25	19	76		44	11	37
	Overall^e	119	104	87		109	35	25

^{^a}

Positive predictive value refers to the number of patients with elevated CTN who had MTC divided by the total number of patients with elevated CTN.

^{^b}

Comparison of proportion with MTC by codon among patients with an elevated preoperative CTN.

^{^c}

False-negative rate refers to the number of patients with normal CTN who had MTC divided by the number of patients who had MTC.

^{^d}

Comparison of proportion of MTC by codon among patients with a normal preoperative CTN.

^{^e}

Overall comparison of MTC rates by whether CTN was elevated or not, p<0.0001.

ATA, American Thyroid Association; CTN, calcitonin.