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. 2014 Jul 1;34(7):526–536. doi: 10.1089/jir.2013.0077

FIG. 5.

FIG. 5.

OM85-BV induced the activation of ERK1/2 through TLR4 and TLR2 signaling pathway. (A, B) RAW264.7 cells transfected with TLR4-siRNA or TLR2-siRNA were cultured with 100 μg/mL OM85-BV for 6 h. The activation of ERK1/2, P38, and AKT in response to OM85-BV was examined by western blot. n ≥3, *P<0.05, #P<0.05, and ☆P<0.05. (C) RAW264.7 cells were transfected with MyD88-siRNA or TRAM-siRNA, respectively, for 48 h, and then cells were stimulated with 100 μg/mL OM85-BV for 6 h. The level of ERK1/2, P38, and AKT phosphorylation was tested by western blot. n ≥3, *P<0.05, #P<0.05, and ☆P<0.05.