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The enzymatic processing of platinated RNAs. (a) Schematic of the products resulting from 5’→3’ (top), 3’→5’ (center) exonuclease or the purine specific endoribonuclease U2 (bottom) digestion of platinated oligonucleotides. (b) MALDI-MS spectra of a platinated 5’-U6-GG-U5-3’ RNA (top) and the platinated 5’-GG-U5-3’ fragment left following nuclease digestion. Adapted with permission from [71]; copyright 2010, American Chemical Society.
