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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 Mar 11;70:100–107. doi: 10.1016/j.yjmcc.2014.02.015

Figure 3. Mechanisms by which class I HDAC inhibition blocks cardiac fibrosis.

Figure 3

Class I HDAC inhibition prevents the differentiation of bone-marrow derived fibrocytes into active fibrocytes and fibroblasts through inhibition of ERK1/2 activation. Class I HDAC inhibition arrests cardiac fibroblasts in G0/G1 of the cell cycle via upregulation of the cyclin-dependent kinase (CDK) inhibitors p15 and p57. Both of these processes result in decreased numbers of activated ECM-producing fibroblasts and myofibroblasts in the myocardium, leading to decreased fibrosis.