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. 2014 Mar 24;592(Pt 12):2549–2561. doi: 10.1113/jphysiol.2013.268680

Figure 6. MitoQ improves resistance to acute mtROS stress in arteries of old mice.

Figure 6

Endothelium-dependent dilation (EDD) dose responses to acetylcholine (ACh) in the absence/presence of rotenone (0.5 μl, 40 min incubation to induce mitochondrial superoxide production) in carotid arteries of young control (YC) and MitoQ-supplemented (YMQ) mice (A) and old control (OC) and MitoQ-supplemented (OMQ) mice (B) (n = 5–6/group). Data are presented on a percentage basis to account for differences in vessel diameter among groups. Data for young and old mice are presented separately for clarity. [*P < 0.05 within-group, dose response to Ach + rotenone vs. dose response to ACh alone; #P < 0.05 vs. OMQ (main effect of group) for dose response to ACh alone.] C, impairment in EDD induced by acute incubation with rotenone (maxEDDACh–maxEDDACh+ROTENONE). Data are presented as means ± s.e.m. (n = 5–6/group; *P < 0.05 vs. within-group maximal dilation to ACh alone).