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. 2014 Mar 31;592(Pt 12):2563–2574. doi: 10.1113/jphysiol.2014.272880

Figure 7. Scheme integrating the blood pressure phenotypes of BKβ1−/− strain A, B and C mice.

Figure 7

BKβ1+/+ control mice displayed increasing mean arterial blood pressure and plasma aldosterone levels from strain A over strain B to strain C. Loss of BKβ1 expression resulted in different phenotypic outcomes depending on strain. In BKβ1−/− strain A mice, plasma aldosterone concentration was increased relative to BKβ1+/+ controls, associated with a hypertensive phenotype that was completely reversible by mineralocorticoid receptor block, indicating a predominantly renal effect. Conversely, BKβ1−/− strain C mice showed a hypotensive phenotype that was alleviated in conjunction with rescue of vascular BK channel activity, indicating this effect originates in smooth muscle. Arrows do not imply direct effects.