Table 2.
Values of pD2 (−log EC50) and Emax (% maximal constriction) responses to endothelial stimulation in small coronary, cerebral, renal, mesenteric and femoral arteries of fetal sheep following alcohol exposure
| pD2 | Emax (% maximal constriction) | |||||
|---|---|---|---|---|---|---|
| Saline | Alcohol | P | Saline | Alcohol | P | |
| No blocker | ||||||
| Coronary | 8.63 ± 0.08 | 8.02 ± 0.18* | 0.01 | 9 ± 4 | 14 ± 9 | 0.62 |
| Mesenteric | 9.82 ± 0.17 | 11.05 ± 0.04* | 0.0001 | 0 ± 0 | 4 ± 2 | 0.21 |
| Renal | 9.29 ± 0.10 | 10.14 ± 0.22* | 0.006 | 1 ± 3 | 4 ± 3 | 0.50 |
| Femoral | 7.45 ± 0.09 | 7.53 ± 0.12 | 0.61 | 1 ± 3 | 4 ± 4 | 0.56 |
| Cerebral | 9.66 ± 0.18 | 9.48 ± 0.08 | 0.38 | 8 ± 7 | 7 ± 4 | 0.90 |
| + l-NAME | ||||||
| Coronary | 7.60 ± 0.23 | 6.88 ± 0.09* | 0.02 | 27 ± 9 | 65 ± 6* | 0.005 |
| Mesenteric | 8.86 ± 0.12 | 9.80 ± 0.16* | 0.0008 | 5 ± 6 | 2 ± 6 | 0.73 |
| Renal | 8.98 ± 0.12 | 9.15 ± 0.25 | 0.55 | 14 ± 8 | 15 ± 10 | 0.96 |
| Femoral | 6.75 ± 0.10 | 6.67 ± 0.11 | 0.56 | 3 ± 4 | 11 ± 5 | 0.24 |
| Cerebral | 8.79 ± 0.31 | 8.73 ± 0.45 | 0.94 | 57 ± 11 | 63 ± 10 | 0.70 |
| + l-NAME + Indo | ||||||
| Coronary | 7.70 ± 0.03 | 7.70 ± 0.40 | 0.99 | 24± 10 | 61 ± 8* | 0.02 |
| Mesenteric | 8.37 ± 0.13 | 9.04 ± 0.11* | 0.003 | 11 ± 10 | 4 ± 8 | 0.60 |
| Renal | 8.30 ± 0.14 | 8.38 ± 0.38 | 0.85 | 6 ± 8 | 16 ± 6 | 0.34 |
| Femoral | 5.97 ± 0.40 | 6.00 ± 0.41 | 0.96 | 19 ± 18 | 32 ± 20 | 0.64 |
| Cerebral | 8.43 ± 0.56 | 6.61 ± 0.67 | 0.06 | 71 ± 10 | 39 ± 21 | 0.20 |
Daily maternal infusion for 1 h of saline (n = 6) or alcohol (n = 6). Concentration–relaxation curves were first obtained in control solution and then in the presence of l-NAME to block NO production, and in l-NAME + indomethacin (Indo) to additionally block prostanoid production. The statistical significance of the data is indicated by P;
*
significant difference between saline and alcohol treatment.