A, contractile responses to U46619 (expressed as % of contraction to high K PSS) in coronary arteries from control, IUGR, melatonin (MT) and IUGR + MT-treated animals (n = 6 per group). B, two-way ANOVA of the maximal response to U46619, effect of IUGR and melatonin. C, endothelium-independent relaxation to sodium nitroprusside (SNP) in coronary arteries from control, IUGR, MT and IUGR + MT-treated animals. †Significantly different from the other 3 groups. *Significant effect of MT.