Table 3.

pD₂ values for endothelium-dependent relaxation in response to bradykinin stimulation in the four treatment groups

	No blocker		l-NAME		l-NAME + Indo
	pD2	P value	pD2	P value	pD2	P value
Control	9.273 ± 0.086		8.136 ± 0.123		8.041 ± 0.147
MT	9.689 ± 0.142	0.025*	8.049 ± 0.108	NS	7.255 ± 0.095	0.001*
IUGR	8.916 ± 0.103	0.021*	8.120 ± 0.060	NS	7.167 ± 0.200	0.006*
IUGR + MT	9.943 ± 0.099	0.0001†	8.188 ± 0.099	NS	7.307 ± 0.144	0.58

Treatment groups are: control, melatonin (MT) treatment, IUGR and IUGR + MT before (no blocker) and following blockade of NO and prostanoid production with l–NAME and indomethacin (Indo), respectively. n = 6 per group. P values:

^*significantly different from control vehicle;

^†significantly different from IUGR treatment. NS, P > 0.05.