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. 2014 Jun 10;142(3):337–346. doi: 10.1111/imm.12269

Figure 2.

Figure 2

The role of iNKT cells in lipid handling and metabolic regulation. iNKT cells and Tregs are enriched in lean adipose tissue where they produce IL-10. During obesity induced adipose expansion, iNKT cells and Tregs are depleted resulting in less IL-10 and a more inflammatory environment, correlating with increased pro-inflammatory macrophage accumulation. Loss of protective cell subsets like iNKT and Tregs in obese adipose tissue contributes to metabolic dysfunction and eventually systemic inflammation.