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Fractionation of serum polyclonal IgG4 into IgG4κ, IgG4λ and hybrid IgG4κ/λ monomers. Polyclonal IgG4 was purified from a pooled human plasma source by affinity chromatography and sequentially fractionated into either IgG4κ or IgG4λ. A substantial portion of purified IgG4 possessed both κ and λ light chains and was further fractionated by HPLC-size-exclusion chromatography.
