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Spontaneous anti-nuclear antibody (ANA) production in sex-matched and age-matched Crp knockout and control wild-type C57BL/6 mice. Open columns, ANA-negative mice with titre < 1/80; solid columns, ANA-positive mice with titre > 1/80. (a) 3 months of age; (b) 6 months; (c) 9 months. Female Crp knockout mice had significantly more ANA by Fisher's exact test at 9 months (P = 0.03) and at 12 months (P = 0.002).
