Figure 5.

(a) Haematopoietic progenitor cells (HPCs) engraft across MHC barriers with minimal pre-conditioning. 129SvJ HPCs were prepared and injected into sub-lethally irradiated BALB/c mice or 129SvJ autologous mice. Mixed chimerism was monitored by flow cytometry over 35 days. More than 20 animals were transplanted in each setting. Mixed chimerism was detected at about the same levels in both strains suggesting that these HPCs did not evoke T-cell-related immune rejection. (b) Representative dot plot showing peripheral blood chimerism.