Figure 6.

Efficacy of systemic delivery of central nervous system (CNS) -targeted mesenchymal stromal cells (MSC)s in experimental autoimmune encephalomyelitis (EAE) mice. Ten mice in three groups were given a low dose (1 × 10⁴) of CARαMOG or mock MSCs or PBS alone by intraperitoneal (i.p.) infusion at peak of EAE inflammation (15 days post-EAE immunization). Ten days post-MSC treatment all mice in the MSC CARαMOG group were cured (**P < 0·01). At end-point (15 days post-treatment) 7/10 mice in the mock-treated group still exhibited EAE symptoms (*P < 0·05). Statistics were analysed using the Mann–Whitney U-test and GraphPad prism software. The challenge experiment was repeated twice with similar results.