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Microvascular water permeability in (+/+) and AQP1 (–/–) mice. The airspace of a perfused lung was filled with an inert perfluorocarbon, and the pulmonary artery was perfused with solutions of indicated osmolalities containing FITC-dextran (see Methods). Representative time course data for lungs of (+/+) mice (left) and AQP1 (–/–) mice (right). Relative fluorescence changes (ΔF/F), which are related to microvascular osmotic water permeability, are summarized in the text.
