Figure 2.

Adoptive transfer of immune cells into NOD.SCID mice. (a) Incidence of hyperglycaemia in NOD.SCID mice following adoptive transfer of 2·5 × 10⁷ CD4⁺ CD25⁻ T cells (n = 26) and in conjunction with 2·5 × 10⁶ CD4⁺ CD25⁺ Treg cells (n = 10) harvested from pre-diabetic NOD females aged 11 weeks. Immune profiles of diabetic and euglycaemic NOD.SCID mice following adoptive transfer of CD4⁺ CD25⁻ (n = 5) and CD4⁺ CD25⁺ Treg cells (n = 8) were determined in the thymus, spleen, mesenteric lymph nodes and pancreatic infiltrates: (b) CD4⁺ CD25⁺ FoxP3⁻, (c) CD4⁺ CD25⁻ FoxP3⁺ and (d) CD4⁺ CD25⁺ FoxP3⁺ T cells.