Figure 4.

Immunophenotyping of diabetic and euglycaemic NOD.SCID recipients of T cells from pre-diabetic and diabetic NOD females. NOD.SCID mice were infused with 2·5 × 10⁷ CD4⁺ CD25⁻ T cells from pre-diabetic (age 11 weeks, n = 26) and new-onset diabetic NOD female (n = 17) mice. Data represent fractional CD25 and FoxP3 expression in the lymph nodes (a–c) and pancreatic infiltrates (d–f) in new-onset diabetic NOD.SCID mice and in euglycaemic mice at the experimental end-point of 25 weeks: (a,d) CD25⁺ FoxP3⁻, (b,e) CD25⁻ FoxP3⁺, (c,f) CD25⁺ FoxP3⁺.