Figure 5.
Migration and activity of grafted T cells. NOD.SCID mice were injected with CFSE-labelled 2·5 × 107 CD4+ CD25− T cells and were killed after 1 and 2 days for analysis of the spleen, mesenteric lymph nodes (LN) and pancreas. (a) Homing of donor T cells to these organs within 1 day, expressed as per cent of the donor inoculum. (b) Proliferation of donor T cells after 1 day, as determined from CFSE dilution and quantified with the ModFit software. (c) Expression of CD25 expressed as per cent of donor T cells homed to the various organs after 1 and 2 days.