Table 1.
NOD.SCID mice were adoptively transferred with 2 × 107 splenocytes, 2·5 × 107 CD4+ CD25− T cells and 2·5 × 106 CD4+ CD25+ regulatory T cells from pre-diabetic (insulitis) and new-onset diabetic NOD female mice
| Insulitis | Diabetes | ||||||
|---|---|---|---|---|---|---|---|
| Incidence (%) | Mean onset time (weeks) | Diabetogenic potential | Incidence (%) | Mean onset time (weeks) | Diabetogenic potential | P-value | |
| Splenocytes | 80 | 6·0 ± 2·3 | 0·16 ± 0·1 | 100 | 4·6 ± 2·1 | 0·26 ± 0·09 | 0·05 |
| CD25+ | 0 | 0 | |||||
| CD25− | 81 | 9·1 ± 3·6 | 0·1 ± 0·08 | 70 | 7·3 ± 1·2 | 0·09 ± 0·07 | |
| CD25− CD25+ | 100 | 13·1 ± 2·5 | 0·08 ± 0·02 | 100 | 13·2 ± 2·5 | 0·09 ± 0·02 | |