Table 1.
Therapeutic applications of Class B receptors and drugs directed at the receptors
| Receptor | Mechanism | Disease | Drug name | Company | Status |
|---|---|---|---|---|---|
| AMY1–3 | Peptide agonist | Diabetes (Type 1 and 2) | Pramlintide | Amylin/Bristol Myers Squibb | Market |
| CT | Peptide agonist | Osteoporosis, hypercalcaemia, Paget's | Salmon calcitonin | Novartis | Market |
| Peptide agonist | Hemiplegia | Elcatonin | Asahi Kasei Pharma Corp | Ph2 | |
| CGRP | Antagonist | Migraine | MK-1602 | Merck | Ph2 |
| Antagonist | Migraine | Telcagepant | Merck | Ph3 discontinued | |
| Antagonist | Migraine | BMS-927711 | Bristol Myers Squibb | Ph2 | |
| CGRP peptide mAb | Migraine | ALD403 | Alder Biopharmaceuticals | Ph2 | |
| CGRP receptor mAb | Migraine | LY-2951742 | Eli Lilly | Ph2 | |
| CRF1 | Antagonist | Depression, PTSD, alcoholism | Verucerfont | Neurocrine | Ph2 |
| Peptide agonist | Cerebral oedema | Corticorelin | Celtic | Ph3 | |
| GHRH | Peptide agonist | HIV-associated lipodystrophy | Tesamorelin | Theratechnologies Inc | Market |
| GLP-1 | Peptide agonist | Type 2 diabetes | Exenatide | Amylin/Bristol Myers Squibb | Market |
| Peptide agonist | Type 2 diabetes | Liraglutide | NovoNordisk | Market | |
| Peptide agonist | Type 2 diabetes | Lixisenatide | Sanofi | Market | |
| Peptide agonist | Type 2 diabetes | Albiglutide | GSK | Market | |
| Peptide agonist | Type 2 diabetes | Dulaglutide | Eli Lilly | Ph3 | |
| Peptidic agonist | Type 2 diabetes | TTP-054 | Transtech Pharma | Ph2 | |
| Multiple other GLP-1 agonists in earlier clinical trials | |||||
| GLP-2 | Peptide agonist | Chemotherapy induced diarrhoea | Elsiglutide | Zealand Pharma | Ph3 |
| Peptide agonist | Short bowel syndrome | Teduglutide | NPS Allelix | Market | |
| Glucagon | Antagonist | Type 2 diabetes | LY-2409021 | Eli Lilly | Ph2 |
| Glucagon/GLP-1 | Dual peptide | Type 2 diabetes | TT-401 | Eli Lilly | Ph1 |
| Glucagon/GLP-1 | Dual peptide | Type 2 diabetes | ZP-2929 | Zealand Pharma | Ph1 |
| Secretin | Peptide agonist | Pancreatic pain | Secretin | ChiRhoClin Inc | Ph2 |
| PTH1 | Peptide agonist | Osteoporosis | Teriparatide | Eli Lilly | Market |