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(A) HG (30 mmol·L−1, 8 h)-induced reduction of glucose-stimulated insulin secretion in INS-1E cells was reversed by berberine (BBR; 5 μmol·L−1). Compound C (CC; 10 μmol·L−1), genipin (1 μmol·L−1) (A) and adenovirus ucp2 short hairpin RNA (B) inhibited the effect of BBR on insulin secretion. Results are means ± SEM of six to eight experiments. *P < 0.001 versus control or control (scramble); #P < 0.05 versus HG or HG (scramble); †P < 0.05 versus HG + BBR or control (shUCP2).
