Table 2.

Effect of Atg5 siRNA on the CI of PI103 and Ku-0063794 in GC cells grown in LG and HG conditions

Cell line	Glucose	CI at fu 0.5
		Control siRNA	Atg5 siRNA
AGS	High	0.98 ± 0.09	0.32 ± 0.01*
	Low	0.08 ± 0.003	3.8 ± 0.9*
HGC27	High	1.1 ± 0.06	0.14 ± 0.06*
	Low	0.04 ± 0.002	4.6 ± 0.18*
MKN45	High	0.98 ± 0.02	1.1 ± 0.05
	Low	0.89 ± 0.04	0.93 ± 0.02
NUGC4	High	1.1 ± 0.28	0.99 ± 0.08
	Low	1.4 ± 0.82	1.3 ± 0.11

The CI values of PI103 and Ku-0063794 (in the presence of the other drug at fixed, non-growth inhibitory concentrations of one-fifth IC₅₀) at fu 0.5 in the presence or absence of Atg5 siRNA are displayed. Additivity = 1, antagonism > 1, synergy < 1.

^*P < 0.05 for differences from unity for CI values.