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. 2014 Jul 3;10(7):e1003675. doi: 10.1371/journal.pcbi.1003675

Figure 3. Schematic of the ODE model.

Figure 3

Background colors represent translocation (orange), unfolding (green), misfolding (yellow), and aggregation/disaggregation (red) modules. Additional states and reactions involving the luminal co-chaperone Scj1 are accounted for in the aggregation, unfolded, and misfolded modules, but are omitted from this diagram due to space limitations. Species are represented as follows: Pore; nascent protein (N), sliding state (x); folded protein (F); unfolded protein (U); misfolded protein (M); BiP; Sec63; size 2 aggregate (A2); size 3 aggregate (A3); size 4 aggregate (A4). Sliding states (x) mimic the movement of the nascent protein further into the lumen.