Table 2. Macrophage cytokine expression in response to NF-κB decoy ODN.
| Classification | Name | Mouse | THP1 |
|---|---|---|---|
| Chemokine -Macrophage | MCP1 | *↓ 27% | *↓ 20% |
| MIP1α | *↓ 83% | *↓ 65% | |
| MIP1β | N.A. | *↓ 66% | |
| RANTES | N.A. | *↓ 63% | |
| -Neutrophil | IL-8 | N.A. | *↓ 54% |
| CXCL1 | *↓ 36% | N.A. | |
| -T cell | IP-10 | N.S. | N.S. |
|
| |||
| Pro-inflammatory cytokines | TNF-α | *↓ 43% | *↓ 49% |
| IL-1α | N.S. | N.A. | |
| IL-1β | *↓ 38% | N.S. | |
| IL-1Ra | N.S. | *↓ 27% | |
| IL-6 | *↓ 84% | *↓ 68% | |
| IL-12 | *↓ 19% | *↓ 37% | |
|
| |||
| Cellular immunity | IL-2R | N.A. | *↓ 19% |
| IL-7 | N.A. | N.D. | |
| IL-10 | N.S. | N.D. | |
| IL-13 | N.S. | N.D. | |
| IL-15 | N.A. | N.S. | |
| IFN-α | N.A. | N.D. | |
N.A. Not available; N.D. Non-detectable; N.S. Not significant.
*
Statistically significant