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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Transl Stroke Res. 2014 Apr 12;5(3):316–329. doi: 10.1007/s12975-014-0343-0

Table 1.

Brain AVM mouse models

Models Onset Advantages Disadvantages
Ad-Cre/AAVVEGF/
Alk1f/f 		Adult Low mortality. No AVM in
other organs.		 Inflammation caused by
adenoviral vector
complicates mechanistic
analysis.
Pdgfb-iCreER/AAVVE
GF/Alk1f/f 		Adult Brain AVM develops in a
relatively shorter time.		 AVM develops in multiple
organs and mice die 10–14 days after tamoxifen-
Rosa-CreER/AAV-VEGF/Engf/f Adult Low mortality. AVM develops in multiple
organs.
SM22α-Cre/Engf/f Embryonic AVM develops
spontaneously. A good
model for mechanistic study
and for new drug testing.		 Embryonic onset. 50%
mice die before 6 weeks
of age.