Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 May 21;42(12):7708–7719. doi: 10.1093/nar/gku417

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 7. — Slow kinetics of incision by hAPE1 of a single AP site located in quadruplex c-myc-AP12. (A) ds-c-myc-AP12 (91 mer) in duplex (left panel) or quadruplex (right panel) DNA conformation; 33 mer, 33 nt long APE1 cleavage product; time points are indicated above each gel picture. (B) Quantitation of the results of three independent hAPE1 experiments. (C) Quantitation of the extent of DNA in duplex or quadruplex structure by BsgI restriction digestion. Broken DNA, 33 mer product generated from cleavage at the AP site during heat denaturation; undigested DNA, 91 mer substrate resistant to BsgI cleavage.