Table 2.
For each KSHV miRNA stem-loop, the absence (N) or presence (Y) of positive structural criteria for Drosha/DGCR8 recognition and cleavage were determined. miRNA stem-loops were ranked in decreasing order of present determinant, defining two main groups (optimal and suboptimal) separated by a dotted line. Numbers in brackets indicate the length of the terminal loop (in nt) and of the basal stem (in bp). Stem-loops giving rise to abundant mature miRNAs in infected BCBL-1 cells are highlighted in gray.
aThe basal stem can be paired at one (+/−, value of 0.5) or both extremities (Y), forming stable platforms.
bOnly presence of a U at position -14 (+/−, value of 0.5).